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. 2009 Dec 4;5(12):e1000588. doi: 10.1371/journal.pcbi.1000588

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Sands et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Inline graphic — Panel (A) shows the increase in the slope of the oxy-hemoglobin dissocation curve at the level of alveolar (), and the fall in pulmonary oxygen uptake () that occurs during apnea. Panel (B) shows that changes in the product explain the time course of the instantaneous slope of arterial O₂ desaturation () during apnea. Note that the peak occurs when is substantially less than its resting value. Note also that the rate of fall of mixed-venous saturation () and become equal and constant after 20 s.

Panel (A) shows the increase in the slope of the oxy-hemoglobin dissocation curve at the level of alveolar (), and the fall in pulmonary oxygen uptake () that occurs during apnea. Panel (B) shows that changes in the product explain the time course of the instantaneous slope of arterial O₂ desaturation () during apnea. Note that the peak occurs when is substantially less than its resting value. Note also that the rate of fall of mixed-venous saturation () and become equal and constant after 20 s.