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. 2009 Dec 4;5(12):e1000588. doi: 10.1371/journal.pcbi.1000588

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Sands et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Inline graphic — (A) Effect of three levels of Hb, (i) 12 g dl⁻¹, (ii) 8 g dl⁻¹ and (iii) 4 g dl⁻¹, on arterial () and mixed venous () O₂ desaturation during apnea. Note the fall in at the inflection point (shown by short black lines). Note also that the reduced Hb has little impact on desaturation above . (B) Sensitivity of to changes in Hb. (C) Effect of three levels of P₅₀, (iv) 18 mmHg, (v) 24 mmHg, and (vi) 36 mmHg, on . (D) Sensitivity of to changes in P₅₀. n = ‘normal’ values; S1, stage 1 slope; S2, stage 2 slope.

(A) Effect of three levels of Hb, (i) 12 g dl⁻¹, (ii) 8 g dl⁻¹ and (iii) 4 g dl⁻¹, on arterial () and mixed venous () O₂ desaturation during apnea. Note the fall in at the inflection point (shown by short black lines). Note also that the reduced Hb has little impact on desaturation above . (B) Sensitivity of to changes in Hb. (C) Effect of three levels of P₅₀, (iv) 18 mmHg, (v) 24 mmHg, and (vi) 36 mmHg, on . (D) Sensitivity of to changes in P₅₀. n = ‘normal’ values; S1, stage 1 slope; S2, stage 2 slope.