Table 2.
Invasive aspergillosis: organ distribution and mortality; 1960–2005. Studies including more than 25 adult patients.
| Organ distribution | |||||||
|---|---|---|---|---|---|---|---|
| Authors | N | Mortality | Lung | Disseminated | CNS | Digestive | Primary digestive |
| Autopsy | |||||||
| Young et al. [12] | 98 | 100% | 92 (94%) | 34 (35%) | 13 (13%) | 21 (21%) | 3 (3%) |
| Meyer et al. [13] | 93 | 100% | 90 (98%) | 23 (35%) | 9 (10%) | 9 (10%) | 1 (1%) |
| Boon et al. [11] | 32 | 100% | 32 (100%) | 20 (63%) | 16 (50%) | 15 (53%) | 0 |
| Vogeser et al. [18] | 27 | 100% | 23 (85%) | 16 (59%) | 12 (44%) | 7 (26%) | 1 (4%) |
| Vogeser et al. [31] | 48 | 100% | 41 (85%) | 28 (58%) | 21 (44%) | 1 (2%) | 0 |
| Hori et al. [56] | 107 | 100% | 105 (98%) | 52 (52%) | 22 (21%) | 12 (11%) | 0 |
| Total | 405 | 100% | 383 (95%) | 176 (43%) | 93 (23%) | 67 (17%) | 5 (1%) |
| Retrospectiva | |||||||
| Fisher et al. [14] | 91 | 88% | 83 (91%) | 20 (22%) | 13 (14%) | 5 (5%) | 1 (1%) |
| Albelda et al. [15] | 26 | 62% | 26 (100%) | NS | NS | NS | NS |
| Morrison et al. [5] | 93 | 62% | 87 (95%) | 43 (47%) | 21 (23%) | NS | 1 (1%) |
| Horvath and | 69 | 52% | 49 (71%) | NS | NS | NS | NS |
| Dummer [33] | |||||||
| Janssen et al. [34] | 25 | 92% | 25 (100%) | 8 (32%) | 3 (12%) | 4 (28%) | 0 |
| Caillot et al. [35] | 37 | 27% | 37 (100%) | 8 (22%) | 0 | 0 | 0 |
| Kaiser et al. [36] | 35 | 97% | 33 (94%) | 8 (23%) | 1 (3%) | 0 | 0 |
| Abbasi et al. [37] | 66 | 85% | 46 (70%) | 23 (35%) | 9 (14%) | 0 | 0 |
| Lortholary et al. [38] | 31 | 45% | 28 (90%) | 7 (23%) | 4 (13%) | 0 | 0 |
| Nosari et al. [39] | 61 | 48% | 56 (92%) | 20 (33%) | 5 (8%) | 0 | 0 |
| Pagano et al. [19] | 391 | 51% | 332 (85%) | NS | 37 ( 9%) | 9 (2%) | 4 (1%) |
| Total | 925 | 60% 555/925 | 802 (87%) | 137/438 (31%) | 92/829 (11%) | 18/737 (2%) | 6/829 (0.7%) |
| Prospective | |||||||
| Ringden et al. [40] | 32 | 34% | 29 (91%) | NS | NS | 0 | NS |
| Denning et al. [20] | 76 | 32% | 51 (67%) | NS | 8 (11%) | NS | 1 (1.3%) |
| Stevens et al. [21] | 125 | 34% | 90 (72%) | 24 (19%) | 8 (6%) | 0 | 1 (0.8%) |
| Denning et al. [22] | 123 | 64% | 106 (87%) | 33 (27%) | 10 (8%) | 0 | 1 (0.8%) |
| Patterson et al. [41] | 595 | 51% | 330 (56%) | 148 (25%) | 34 (6%) | NS | NS |
| Denning et al. [42] | 116 | 58% | 81 (70%) | 6 (5%) | 19 (16%) | 0 | 0 |
| Bowden et al. [44] | 174 | 53% | 107 (62%) | NS | 12 (7%) | NS | NS |
| Herbrecht et al. [43] | 277 | 35% | 240 (87%) | 15 (5%) | 10 (4%) | NS | NS |
| Total | 1,518 | 47% | 1,034 (64%) | 226/1,236 (18%) | 101/1,486 (7%) | 0/396 (0%) | 3/440 (0.7%) |
| 716/1518 | |||||||
| All studies | 2,848 | 59% | 2,219 (78%) | 539/2,079 (26%) | 296/2,720 (11%) | 85/1,538 (5.5%) | 14/1,674 (0.8%) |
| 1676/2848 | |||||||
NS: not specified