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. Author manuscript; available in PMC: 2010 Mar 1.
Published in final edited form as: Biochem J. 2009 Mar 1;418(2):261–275. doi: 10.1042/BJ20082055

Figure 5.

Figure 5

The Metabolic Syndrome can be defined as a disorder in which combinations of overnutrition, inactivity and as yet poorly defined genetic factors results in a state of metabolic dysregulation characterized by lipid abnormalities, insulin resistance and inflammation. This in turn can predispose to one or more of the shown disorders. Apart from inactivity being a causal factor, exercise has demonstrated efficacy in treating and preventing both the state of metabolic dysregulation and many of the diseases to which it predisposes. See text for details. NAFLD-NASH: non-alcoholic fatty liver disease. PCOS: Policystic ovary syndrome.