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. Author manuscript; available in PMC: 2010 Mar 1.
Published in final edited form as: Biochem J. 2009 Mar 1;418(2):261–275. doi: 10.1042/BJ20082055

Table 1.

Some rodents in which decreased AMPK activity is associated with the metabolic syndrome

Rodent Comment Refs
FaFa rat Defective leptin receptor, obese, insulin resistant,non-diabetic [224]
ZDF rat Defective leptin receptor, obese, insulin resistant, diabetic [224]
IL-6 KO mouse Decreased AMPK activity and an impaired ability to exercise precedes obesity,
dyslipidemia and impaired glucose tolerance		 [89;207]
Glucose-infused
rat (5–24h)		 Decreased AMPK activity in muscle and liver appears concurrent with
increased tissue triglyceride and insulin resistance		 [101]
ObOb mouse Leptin deficient, obese, insulin resistant [106;224]