Table 4. Haplotype Association analysis between the LOXL1 SNPs and XFS/XFG.
| Haplotype | Proportion |
x2 | p value | OR (95%CI) | |||
|---|---|---|---|---|---|---|---|
| Case | Control | ||||||
|
rs1048661 |
rs3825942 |
||||||
| T |
G |
|
0.89 |
0.516 |
22.09 |
<1.00×10-3 |
6.77 (2.69 - 17.03) |
| G |
G |
|
0.11 |
0.38 |
11.67 |
0.001 |
0.22 (0.09 - 0.55) |
| G |
A |
|
0 |
0.104 |
4.21 |
0.04 |
NA * |
| Total |
|
|
NA |
NA |
20.36 |
<1.00×10-3 |
NA |
|
rs1048661 |
rs2165241 |
||||||
| T |
C |
|
0.88 |
0.516 |
20.47 |
<1.00×10-3 |
6.99 (2.78 - 17.58) |
| G |
T |
|
0.01 |
0.1 |
8.12 |
0.004 |
0.08 (0.01 - 0.62 ) |
| T |
T |
|
0.01 |
0 |
2.52 |
0.112 |
NA * |
| G |
C |
|
0.1 |
0.384 |
13.64 |
<1.00×10-3 |
0.18 (0.07 - 0.48) |
| Total |
|
|
NA |
NA |
19.70 |
<1.00×10-3 |
NA |
|
rs3825942 |
rs2165241 |
|
|||||
| G |
C |
|
0.98 |
0.8 |
9.15 |
0.002 |
12.18 (1.61 - 92.09) |
| G |
T |
|
0.02 |
0.1 |
1.95 |
0.163 |
NA * |
| A |
C |
|
0 |
0.1 |
9.159 |
0.002 |
0.001(0 - inf) |
| Total |
|
|
NA |
NA |
13.45 |
0.001 |
NA |
|
rs1048661 |
rs3825942 |
rs2165241 |
|||||
| T |
G |
C |
0.88 |
0.516 |
19.70 |
<1.00×10-3 |
6.77 (2.69 - 17.03) |
| G |
G |
C |
0.1 |
0.29 |
7.04 |
0.008 |
0.28 (0.10 - 0.75) |
| G |
G |
T |
0.01 |
0.09 |
2.59 |
0.108 |
NA |
| T |
G |
T |
0.01 |
0 |
2.51 |
0.113 |
NA * |
| G |
A |
C |
0 |
0.094 |
3.76 |
0.052 |
NA * |
| G |
A |
T |
0 |
0.01 |
0.40 |
0.526 |
NA * |
| Total | NA | NA | 20.37 | <1.00×10-3 | NA | ||
The haplotypes T-G, T-C and G-C for the SNPs rs1048661 and rs3825942, rs1048661 and rs2165241, and rs3825942 and rs2165241 were identified to be significantly associated with XFS, respectively. The haplotype T-G-C for the three SNPs was identified to be significantly associated with XFS. Total indicate omnibus tests, while the others indicate the haplotype-specific tests. The OR values were obtained from comparision of each individual haplotype with all the other haplotypes, i.e., T-G versus G-G + G-A for the SNPs rs1048661 and rs3825942, et al. NA: not available. The asterisks indicate that the OR values were not available since differences between cases and controls were not significant for these haplotypes (p>0.017).