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. 2009 Oct 13;5:312. doi: 10.1038/msb.2009.70

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Copyright © 2009, EMBO and Nature Publishing Group

This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits distribution and reproduction in any medium, provided the original author and source are credited. Creation of derivative works is permitted but the resulting work may be distributed only under the same or similar licence to this one. This licence does not permit commercial exploitation without specific permission.

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DNA replication-dependent and Mcm2–7 origin binding-dependent gene expression. Raster display, in which the expression of each gene is centered at its time-invariant level. (A) DNA replication is required for efficient histone gene expression. Raster display of histone gene expression shows that histone genes are overexpressed in the Cdc6⁺/45⁺ control, relative to the Cdc6⁻ condition, and to a lesser extent also relative to the Cdc45⁻ condition, in a highly correlated manner. (B) Origin licensing decreases the expression of genes with origins near their 3′ ends. Raster display of the expression of the 16 most significant genes in this class shows that these genes are overexpressed in the Cdc6⁻ relative to the Cdc45⁻ time courses, and to a lesser extent also relative to the control, in a manner less correlated than that of the histone genes.