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. 2009 Nov 16;187(4):513–524. doi: 10.1083/jcb.200907047

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© 2009 Wu et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 2. — Immortal germ cells are SSCs. (A) Outline of the experimental protocol to yield single cell–derived long-lasting clones and subsequent transplantation of cells from these clones into presterilized recipient rat testes. (B) A wild-type recipient testis transplanted with a long-lasting clone derived from single EGFP-positive germ cell. The donor SSC-derived EGFP-positive spermatogenic colonies (left) indicate the founding cell of the long-lasting clone was an SSC. An enlarged view of individual donor SSC derived colonies (right) showed multiple layers of differentiating germ cells. This testis is representative of the 26 recipient testes, all of which were colonized similarly by donor SSCs from long-lasting clones. White boxes indicate sections that have been enlarged. Bars: (left) 500 µm; (right) 100 µm.