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. 2009 Nov 2;187(3):319–326. doi: 10.1083/jcb.200908074

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© 2009 Messick and Greenberg

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 3. — Model for differential ubiquitin-related recognition and repair activities at DSBs. Ubiquitin chains of differing topologies, as indicated, covalently linked to different substrate proteins create a varied ubiquitin landscape at DSBs. Differential recognition of this ubiquitin environment by DNA repair proteins targets repair and checkpoint activities to the appropriate location adjacent to DSBs.