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. 2009 Nov 2;187(3):429–442. doi: 10.1083/jcb.200904049

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© 2009 Brunelle et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 3. — BH3 profiling distinguishes BCL-2– and MCL-1–dependent leukemias. Each profile is an average and standard deviation of three independent experiments, except for the JC1 whole-cell assay. The JC1 whole-cell assay is one experiment done in triplicate, with the average of the three repeats presented here. (A) BH3 profile of Mcl-1/Eμ-Myc primary leukemia cells. (B) BH3 profile of Mcl-1/Eμ-Myc cell line. (C) BH3 profile of Mcl-1/Eμ-Myc cell line using the JC1 whole-cell assay. (D) BH3 profile of BCL-2/ Eμ-Myc primary leukemia cells. (E) BH3 profile of BCL-2/Eμ-Myc cell line. (F) BH3 profile of BCL-2/Eμ-Myc cell line using the JC1 whole-cell assay. (G) Cell lines were treated with doxycycline for 7 d and survival assessed as the Annexin V negative population, measured by FACS. Data presented are from a single experiment; the experiment was repeated twice.