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. 2009 Nov 2;187(3):429–442. doi: 10.1083/jcb.200904049

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© 2009 Brunelle et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 5. — BH3 profiling of Eμ-Myc tumors reveals variable dependence on anti-apoptotic proteins. Data presented are from one single experiment. (A) Eμ-Myc tumor #859 shows a MCL-1 profile. (B) Eμ-Myc tumor #1107 shows a profile where MCL-1 > BCL-2/BCL-XL. (C) Eμ-Myc tumor #1433 shows a profile where MCL-1 > BCL-2/BCL-XL. (D) Eμ-Myc tumor #1656 shows a profile where BCL-2/BCL-XL > MCL-1. (E) Western blot containing CHAPS lysates of the Eμ-Myc tumors in order to compare protein levels of anti-apoptotic proteins BCL-2, BCL-XL, and MCL-1. Note low BCL-2 protein level in Eμ-Myc tumor #859.