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. 2009 Nov 2;187(3):429–442. doi: 10.1083/jcb.200904049

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© 2009 Brunelle et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 8. — Varied chemotherapeutics induce MCL-1 before cell death. All cell lines pretreated with 20 μM of caspase inhibitor Q-VD-OPH for 1 h. CHAPS lysates were prepared and MCL-1, BCL-2, BIM, and Actin protein levels were determined using Western blotting. (A) Mcl-1/Eμ-Myc cell lines treated with 1 μM Bortezomib or 1 μM Flavopiridol for 0, 8, and 16 h. (B) Mcl-1/Eμ-Myc cell lines treated with 1 μM Etoposide for 0, 8, 16, and 24 h. (C) Mcl-1/Eμ-Myc cell lines treated with 1 μM Vincristine for 0, 8, 16, and 24 h. (D and E) BCL-2/Eμ-Myc cell lines treated with 1 μM Etoposide or 1 μM Vincristine for 0, 8, 16, and 24 h. (F) BCL-2/Eμ-Myc cell lines treated with 1 μM Bortezomib for 0, 8, and 16 h. (G) BCL-2/Eμ-Myc cell lines treated with 1 μM Flavopiridol for 0, 8, and 16 h.