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. Author manuscript; available in PMC: 2010 Dec 1.
Published in final edited form as: Drug Alcohol Depend. 2009 Sep 1;105(3):234–239. doi: 10.1016/j.drugalcdep.2009.07.007

Table 2.

Summary of steady-state pharmacokinetics for TPV/r in the presence and absence of steady-state BUP/NLX

Treatment N Arithmetic mean (median, minimum - maximum)a
AUC0–12h Cmax Cmin
TPV/r + BUP/NLX 10 694
(688, 413 – 1141)		 95.7
(95.5, 71.7 – 125.8)		 34.6
(34.2, 7.4 – 75.6)
TPV/r alone 161 859
(859, 756 – 979)		 128.1
(128.1, 112.4 – 143.5)		 33.6
(33.6, 26.9 – 42.2)
Mean Ratio (90% CI)b 0.81 (0.63, 1.02) 0.75 (0.65, 0.86) 1.03 (0.58, 1.53)
a

Represents the arithmetic mean, median, minimum and maximum values for the resampled data sets.

b

Represents the arithmentic mean ratio for the comparison of the pharmacokinetic parameter and the respective 5th and 95th percentiles of the distribution of the ratio; a value of 1.00 indicates no change.