Table 3.
Age specific models for reflux related hospital admissions, with unadjusted and adjusted incident rate ratios
| Age at fundoplication | Incidence rate ratio (95% CI) | |
|---|---|---|
| Unadjusted | Adjusted | |
| Aspiration pneumonia | ||
| 0 to <3 months | 0.17 (0.08 to 0.33) | 0.16 (0.08 to 0.33) |
| 3 to <6 months | 0.37 (0.25 to 0.55) | 0.41 (0.27 to 0.61) |
| 6 to <12 months | 0.60 (0.47 to 0.78) | 0.61 (0.46 to 0.79) |
| 12 months to <18 months | 0.86 (0.66 to 1.13) | 0.87 (0.66 to 1.15) |
| 18 months to <3 years | 0.74 (0.58 to 0.94) | 0.75 (0.59 to 0.96) |
| ≥3 years | 1.31 (0.94 to 1.82) | 1.35 (0.97 to 1.88) |
| Gastro-oesophageal reflux disease | ||
| 0 to <3 months | 0.27 (0.22 to 0.34) | 0.27 (0.21 to 0.33) |
| 3 to <6 months | 0.39 (0.35 to 0.45) | 0.40 (0.35 to 0.46) |
| 6 to <12 months | 0.57 (0.51 to 0.62) | 0.55 (0.50 to 0.61) |
| 12 months to <18 months | 0.70 (0.62 to 0.79) | 0.70 (0.62 to 0.79) |
| 18 months to <3 years | 0.74 (0.66 to 0.82) | 0.75 (0.67 to 0.83) |
| ≥3 years | 1.12 (0.94 to 1.32) | 1.10 (0.93 to 1.31) |
| Mechanical ventilation | ||
| 0 to <3 months | 0.17 (0.13 to 0.22) | 0.17 (0.13 to 0.23) |
| 3 to <6 months | 0.25 (0.21 to 0.29) | 0.25 (0.21 to 0.30) |
| 6 to <12 months | 0.41 (0.36 to 0.47) | 0.41 (0.36 to 0.47) |
| 12 months to <18 months | 0.56 (0.46 to 0.67) | 0.56 (0.46 to 0.68) |
| 18 months to <3 years | 0.54 (0.44 to 0.65) | 0.54 (0.44 to 0.65) |
| ≥3 years | 1.21 (0.91 to 1.60) | 1.18 (0.89 to 1.57) |
| Pneumonia (non-aspiration) | ||
| 0 to <3 months | 1.63 (0.82 to 3.26) | 1.77 (0.85 to 3.67) |
| 3 to <6 months | 0.95 (0.71 to 1.26) | 0.95 (0.71 to 1.27) |
| 6 to <12 months | 1.03 (0.88 to 1.22) | 1.04 (0.87 to 1.23) |
| 12 months to <18 months | 0.82 (0.67 to 1.00) | 0.82 (0.67 to 1.00) |
| 18 months to <3 years | 1.02 (0.86 to 1.21) | 1.02 (0.85 to 1.21) |
| ≥3 years | 2.11 (1.71 to 2.6) | 2.14 (1.73 to 2.64) |
| Asthma | ||
| 0 to <3 months | 1.98 (0.71 to 5.52) | 1.79 (0.64 to 5.05) |
| 3 to <6 months | 1.56 (0.99 to 2.45) | 1.70 (1.05 to 2.76) |
| 6 to <12 months | 2.59 (2.04 to 3.29) | 2.84 (2.19 to 3.67) |
| 12 months to <18 months | 1.57 (1.28 to 1.91) | 1.49 (1.22 to 1.83) |
| 18 months to <3 years | 1.24 (1.07 to 1.44) | 1.25 (1.08 to 1.46) |
| ≥3 years | 1.70 (1.37 to 2.12) | 1.63 (1.30 to 2.03) |
| Any reflux related hospital admission | ||
| 0 to <3 months | 0.30 (0.26 to 0.35) | 0.29 (0.25 to 0.34) |
| 3 to <6 months | 0.40 (0.37 to 0.44) | 0.41 (0.38 to 0.45) |
| 6 to <12 months | 0.66 (0.62 to 0.70) | 0.66 (0.62 to 0.70) |
| 12 months to <18 months | 0.79 (0.73 to 0.85) | 0.78 (0.72 to 0.85) |
| 18 months to <3 years | 0.81 (0.76 to 0.87) | 0.82 (0.77 to 0.88) |
| ≥3 years | 1.40 (1.27 to 1.55) | 1.39 (1.26 to 1.54) |