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. 1998 May 26;95(11):6454–6459. doi: 10.1073/pnas.95.11.6454

Figure 4.

Figure 4

(A) Statistical parametric map overlaid on an MRI template of areas of increased blood flow with mental stress versus counting control in mental stress ischemic CAD patients (n = 3) versus mental stress nonischemic CAD patients (n = 7). There were significant increases in left hippocampus (x = 22, y = −22, z = −8, z score = 4.43, P < 0.001); left parietal cortex (inferior parietal lobule) (40) (x = 40, y = −54, z = 44, z score = 3.80, P < 0.001); left superior frontal gyrus (8) (x = 26, y = 16, z = 52, z score = 3.83, P < 0.001); left middle frontal gyrus (10) (x = 28, y = 36, z = −4, z score = 3.58, P < 0.001); posterior cingulate, corpus callosum (x = 24, y = −62, z = 12, z score = 3.65, P < 0.001); right hippocampus (x = −26, y = −36, z = −24, z score = 3.44, P < 0.001); temporal pole (38) (x = −44, y = 14, z = −16, z score = 3.45, P < 0.001); precuneus (31) (x = −14, y = −58, z = 36, z score = 3.19, P < 0.001); visual association cortex (18) (x = 22, y = −86, z = −12, z score = 3.15, P < 0.001). (B) Statistical parametric map overlaid on an MRI template of areas of decreased blood flow with mental stress versus counting control in mental stress ischemic CAD patients (n = 3) versus mental stress nonischemic CAD patients (n = 7). There were significant decreases in right superior temporal gyrus (22) (x = −58, y = −42, z = 12, z score = 4.84, P < 0.001); right-middle temporal gyrus (37) (x = −46, y = −56, z = −8, z score = 3.60, P < 0.001); left anterior cingulate (x = 8, y = 42, z = 8, z score = 3.91, P < 0.001); right anterior cingulate (24) (x = −8, y = 6, z = 36, z score = 2.89, P = 0.002); visual association cortex (18) (x = −36, y = −88, z = 12, z score = 3.73, P < 0.001); area 19 (x = 34, y = −76, z = 36, z score = 2.66, P < 0.001); right-middle frontal gyrus (10) (x = −24, y = 48, z = 16, z score = 3.61, P < 0.001); insula (x = −32, y = 0, z = 0, z score = 3.45, P < 0.001); precentral (x = −52, y = −6, z = 32, z score = 2.81, P = 0.002); lingual gyrus (x = −16, y = −70, z = 0, z score = 2.39, P = 0.008).