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. 2009 Dec 1;4(12):e8040. doi: 10.1371/journal.pone.0008040

Figure 5. Identification of essential feedback pathways through in silico perturbation study.

Figure 5

Each column represents a different architecture containing. A) Original ERK+JNK+IKK feedback pathways, B) Only with IKK+JNK feedback pathways, C) Only with ERK+JNK feedback pathways, and D) Only with ERK+IKK feedback pathways. Row 1 the model simulation is performed without any perturbations. Row 2 the model simulation is performed on IKK inhibition. Row 3 the model simulation is performed on JNK inhibition. Row 4 the model simulation is performed on ERK inhibition. E) Western blot: effects of JNK, IKK and ERK inhibitors on the phosphorylation of IRS1 upon simulation with 1 nM insulin for 15 mins.