Figure 2.

ECGs of three different family members carrying the SCN5a 1795insD mutation where the huge phenotypic variability and overlap syndrome can be clearly appreciated. The presence of this overlap syndrome brought us to recognise several mutation carriers who were not earlier linked to the family. ECG A shows predominantly a long-QT syndrome type 3 phenotype with excessive QT prolongation during bradycardia. ECG B shows predominantly a Brugada syndrome phenotype with elevated coved-type ST segments, low initial R waves in the right precordial leads, broad P waves and QRS complexes, but also QT prolongation. ECG C shows a milder mixed phenotype with a first-degree AV block, wide QRS complexes, a coved-type like ST-segment in V1 and QT prolongation.