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. 2009 Nov 30;4(11):e8075. doi: 10.1371/journal.pone.0008075

Figure 1. Cross-species genomic comparison.

Figure 1

A, Schematic for cross species genomic comparison using GSEA. B, The LSL-KrasG12D; Trp53FloxFlox sarcoma geneset (Table S3) is highly enriched in human MFH in the Nakayama et al. soft tissue sarcoma dataset [10] [p = 0.0014; False Discovery Rate (FDR) = 0.012; Enrichment Score (ES) = 0.74; Normalized Enrichment Score (NES) = 2.09]. C, Conversely, a human MFH geneset (Table S4) is strongly enriched in the mouse model of soft tissue sarcoma (p<0.001, FDR<0.001, ES = 0.637 NES = 2.78).