Table 1. GSEA results for the LSL-KrasG12D; Trp53Flox/Flox geneset derived from the mouse model of soft tissue sarcoma (Table S3).
Nakayama [10] | Detwiller [9] | Baird [8] | |
Malignant Fibrous Histiocytoma | 0.001 (0.012) | 0.014 (0.149) | 0.024 (0.190) |
Myxofibrosarcoma | 0.162 (0.559) | - | - |
Fibrosarcoma | 0.177 (0.326) | 0.159 (0.784) | DNE |
Leiomyosarcoma | 0.262 (0.673) | 0.854 (0.981) | 0.401 (0.715) |
Synovial Sarcoma | DNE | DNE | DNE |
Myxoid Liposarcoma | DNE | - | - |
Dedifferentiated Liposarcoma | DNE | - | - |
Rhabdomyosarcoma | - | - | 0.586 (0.781) |
Ewing's Sarcoma | - | - | DNE |
The mouse sarcoma geneset was used to examine three human soft tissue sarcoma datasets [8], [9], [10]. Only undifferentiated pleomorphic sarcoma/MFH demonstrated statistically significant enrichment. Table denotes p-values with FDR in parentheses. Bolded results note significance with p<0.05; FDR<0.25. DNE = Did Not Enrich, dash marks represent insufficient data points to do comparison.