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. 2009 Nov 30;4(11):e8075. doi: 10.1371/journal.pone.0008075

Table 1. GSEA results for the LSL-KrasG12D; Trp53Flox/Flox geneset derived from the mouse model of soft tissue sarcoma (Table S3).

Nakayama [10] Detwiller [9] Baird [8]
Malignant Fibrous Histiocytoma 0.001 (0.012) 0.014 (0.149) 0.024 (0.190)
Myxofibrosarcoma 0.162 (0.559) - -
Fibrosarcoma 0.177 (0.326) 0.159 (0.784) DNE
Leiomyosarcoma 0.262 (0.673) 0.854 (0.981) 0.401 (0.715)
Synovial Sarcoma DNE DNE DNE
Myxoid Liposarcoma DNE - -
Dedifferentiated Liposarcoma DNE - -
Rhabdomyosarcoma - - 0.586 (0.781)
Ewing's Sarcoma - - DNE

The mouse sarcoma geneset was used to examine three human soft tissue sarcoma datasets [8], [9], [10]. Only undifferentiated pleomorphic sarcoma/MFH demonstrated statistically significant enrichment. Table denotes p-values with FDR in parentheses. Bolded results note significance with p<0.05; FDR<0.25. DNE = Did Not Enrich, dash marks represent insufficient data points to do comparison.