. Author manuscript; available in PMC: 2010 May 1.

Published in final edited form as: Hum Mutat. 2009 May;30(5):771–775. doi: 10.1002/humu.20944

Table 1.

Origin of non-disjunction (NDJ) and chromosome 21 gene-marker recombination analysis in Down syndrome (DS) individuals with or without Hirschsprung disease (HSCR).

	Number (%) of cases
	DS with HSCR	DS without HSCR
Sample size	23	23
	Origin of NDJ
Maternal origin of NDJ	21 (91)	22 (96)
Meiosis I NDJ	17 (74)	18 (78)
Genes	Tetratype frequency
SOD1	0.17 ±0.08	0.10 ±0.06
IL10RB, IFNGR2, SON, CBR1	0.33 ±0.10	0.21 ±0.09
TTC3	0.45 ±0.11	0.22 ±0.10
TFF3	0.61± 0.10	0.96 ±0.04
CSTB, PFKL	0.64 ±0.10	1.00 ±0.00

The analyses are based on a set of 23 DS trios with HSCR matched with a set of 23 DS trios without HSCR.