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. Author manuscript; available in PMC: 2010 Oct 1.
Published in final edited form as: Transl Res. 2009 Jul 31;154(4):183–193. doi: 10.1016/j.trsl.2009.07.003

Figure 1. EDHF-mediated relaxation is impaired in SHRSP small mesenteric arteries.

Figure 1

Concentration-response curves to ACh (1nM to 100µM) in U-46619-contracted (0.3µM) second-order mesenteric arteries from (■) WKY and (●) SHRSP, in the absence (A) or in the presence (B) of L-NAME (100µM) and indomethacin (10µM). Experimental values of the relaxation induced by ACh were calculated relative to the maximal changes from the contraction produced by U-46619 in each tissue, which was taken as 100%. Results are presented as mean ± SEM of n=8 in each experimental group. *, P<0.05 compared with WKY.