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. Author manuscript; available in PMC: 2010 Oct 1.
Published in final edited form as: Transl Res. 2009 Jul 31;154(4):183–193. doi: 10.1016/j.trsl.2009.07.003

Figure 5. EDHF-induced relaxation is completely abolished after simultaneous inhibition of IKCa and SKCa.

Figure 5

Concentration-response curves to ACh in U-46619-contracted (0.3µM) second-order mesenteric arteries from (A) WKY and (B) SHRSP in the absence (closed symbols) or presence (open symbols) of UCL-1684 (0.1µM) and TRAM-34 (10µM). All the curves were performed in the presence of L-NAME (100µM) and indomethacin (10µM). Experimental values of the relaxation induced by ACh were calculated relative to the maximal changes from the contraction produced by U-46619 in each tissue. Results are presented as mean ± SEM of n=5 in each experimental group. *, P<0.05 compared with respective control (vehicle).