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. Author manuscript; available in PMC: 2010 Oct 1.
Published in final edited form as: Transl Res. 2009 Jul 31;154(4):183–193. doi: 10.1016/j.trsl.2009.07.003

Figure 6. Relaxation-response to IKCa and SKCa, but not BKCa, channels opener is impaired in SHRSP small mesenteric arteries.

Figure 6

Concentration-response curves to (A) NS309 (1nM to 100µM) and (B) NS1619 in U-46619-contracted (0.3µM) second-order mesenteric arteries from WKY (■) and SHRSP (●). All the curves were performed in the presence of L-NAME (100µM) and indomethacin (10µM). Experimental values of the relaxation induced by NS-309 were calculated relative to the maximal changes from the contraction produced by U-46619 in each tissue. Results are presented as mean ± SEM of n=5 in each experimental group. * P<0.05 vs. WKY.