Table 1. pD₂ and E_max values for ACh-induced dilation in arteries from WKY and SHRSP.

pD₂ values are −log EC₅₀ and Emax values represent the percentage of relaxation of U-46419 Experimental values of the relaxation induced by ACh were calculated relative to the maximal changes from the contraction produced by U-46619 in each tissue, which was taken as 100%. Results are presented as mean ± SEM of n=8 in each experimental group.

	WKY		SHRSP
	pD2	Emax	pD2	Emax
Vehicle	8.0±0.01	102.2±1.4	8.2±0.11*	87.7±5.8*
L-NAME + Indomethacin	7.8±0.08*	100.6±0.6	7.8±0.22	38.4±1.6*†
Iberiotoxin L-NAME + Indomethacin	7.6±0.01	94.2±1.8	6.4±0.02*‡	50.7±3.6*‡
UCL-1684 L-NAME + Indomethacin	6.7±0.03‡	17.3±2.4‡	8.1±0.15*‡	14.6±2.4‡
TRAM-34 L-NAME + Indomethacin	7.5±0.07	86.0±2.7‡	7.4±0.12*‡	7.5±0.5*‡
Charybdotoxin L-NAME + Indomethacin	7.4±0.04	97.4±0.9‡	7.8±0.31*‡	7.4±0.01‡
UCL-1684 + TRAM-34 L-NAME + Indomethacin	7.1±0.02‡	8.6±1.5‡	6.6±0.15*‡	7.3±1.1‡

^*P<0.05 vs. WKY

^†P<0.05 vs. respective vehicle-treated

^‡P<0.05 vs. respective L-NAME and indomethacin-treated.