Table 2.

Cardiac chamber hypertrophy, ECM and titin isoform profile

	Normal (NL, n=6)	Heart Failure (HF, n=6)	p HF vs NL
Cardiac chamber hypertrophy
LA weight/body weight (g/Kg)	0.40±0.11	1.03±0.16	<0.0001
RA weight/body weight (g/Kg)	0.27±0.04	0.72±0.13	<0.0001
RV weight/body weight (g/Kg)	1.38±0.28	1.54±0.08	0.3
LV weight/body weight (g/Kg)	4.07±0.61	5.22±0.61	0.01
Cardiac chamber collagen
LA collagen (μg/mg tissue)	12.9 ± 6.3*	10.9 ± 0.6*	0.6
RA collagen (μg/mg tissue)	18.5 ± 4.1*	12.7 ± 2.3*	0.02
LV collagen (μg/mg tissue)	5.0 ± 1.6	4.9 ± 0.6	0.6
Cardiac chamber N2BA:N2B expression
LA N2BA:N2B ratio	1.5±0.5*	0.58±0.12	0.003
RA N2BA:N2B ratio	0.97±0.17*	0.64±0.1	0.01
RV N2BA:N2B ratio	1.30±0.4*	0.85±0.2	0.04
LV N2BA:N2B ratio	0.68 ± 0.10	0.63 ± 0.13	0.4

^*p < 0.05 vs LV

Abbreviations: LA, left atrial; RA, right atrial; RV, right ventricular; LV, left ventricular