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. 2008 Dec 6;384(1):209–215. doi: 10.1016/j.virol.2008.10.036

Fig. 4.

Fig. 4

The IFN-γ-mediated antiviral effect is not dependent upon expression of CXCL9 or CXCL10. Expression of the non-ELR CXC chemokines CXCL9 (A) and CXCL10 (B) was determined by ELISA at 12 and 24 h following either infection with JHMV alone or IFN-g-treatment of infected cultures. JHMV infection did not result in detectable protein levels for either CXCL9 or CXCL10. Treatment of infected cultures with IFN--treatment of infected cultures. JHMV infection did not result in detectable protein levels for either CXCL9 or CXCL10. Treatment of infected cultures with IFN-γ (100 U/ml) did result in elevated levels of both CXCL9 and CXCL10. IFN-γ treatment of JHMV-infected cells derived from either CXCL10−/− mice (C) or CXCR3−/− mice (D) resulted in significant (⁎p < 0.05) reduction in viral replication at 24 h p.i. Results shown in (A) and (B) are representative of two independent experiments. Results in (C) and (D) are presented as average ± SEM and represent two independent experiments.