Table 3.

Evaluation of Candidate Mediators of the Association of Fetuin-A with Incident Diabetes

	Tertile 1	Tertile 2	Tertile 3
	HR; (95% CI); P-value	HR; (95% CI); P-value	HR; (95% CI); P-value	P for Trend
Fetuin-A Range (g/L)	≤0.76	0.77 – 0.97	> 0.97
Unadjusted	Reference	1.60; (0.94–2.73); 0.08	2.19; (1.31–3.65); < 0.01	< 0.01
Demographic Adjusted *	Reference	1.64; (0.96–2.80); 0.07	2.23; (1.34–3.73); < 0.01	< 0.01
Demographic Adjusted * + Visceral Adiposity	Reference	1.32; (0.73–2.36); 0.36	1.72; (0.98–3.05); 0.06	0.05
Demographic Adjusted* + PAI-1, Adiponectin, and Leptin	Reference	1.71; (0.95–3.10); 0.08	1.94; (1.09–3.45); 0.03	0.02
Demographic Adjusted* + TNFα + IL-6	Reference	1.61; (0.90–2.89); 0.11	2.38; (1.37–4.15); < 0.01	< 0.01
Fully Adjusted for All Candidate Mediators †	Reference	1.83; (0.80–4.17); 0.15	2.44; (1.14–5.22); 0.02	0.02

^*Adjusted for age, sex, and race.

^†Adjusted for age, sex, race, visceral adiposity, PAI-1, adiponectin, leptin, TNFα, and IL-6