. Author manuscript; available in PMC: 2009 Nov 20.

Published in final edited form as: Arthritis Rheum. 2008 Sep;58(9):2874–2881. doi: 10.1002/art.23752

Table 2.

Non-synonymous coding SNPs in GLUT9, linkage disequilibrium with strongest signal in genome wide scan and each other, effect size controlling for age, sex and family structure (simple model) and age, sex, family structure and other SNPs (full model).

		Allele	Linkage Disequilibrium (r²)				Simple Model		Full Model
SNP	rsNumber	Frequency	Rs10489070	Val253Ile	Arg265His	Pro321Leu	Effect Size (SE); mg/dl	p	Effect Size (SE); mg/dl	p
Ala17Thr	rs6820230	0.16	0.01	0.00	0.02	0.14	0.01 (0.07)	0.92	0.01 (0.08)	0.87
Val253Ile	rs16890979	0.17	0.71		0.02	0.09	0.44 (0.06)	1.43 × 10⁻¹¹	0.43 (0.07)	7.89 × 10⁻⁹
Arg265His	rs3733591	0.12	0.02			0.00	0.10 (0.07)	0.16	0.03 (0.07)	0.65
Pro321Leu	rs2280205	0.46	0.18				0.12 (0.05)	0.01	0.00 (0.06)	0.94