Table 4.

Association between uric acid and other quantitative traits in the HAPI Heart Study. Point estimates are effect on trait with each increase of 1 mg/dl of uric acid.

	Men		Women
Trait	Point Estimate (95% CI)	p	Point Estimate (95% CI)	p
Triglycerides (mg/dl)	10.12 (13.36, 6.88)	<0.0001	19.42 (23.76, 15.09)	<0.0001
Fasting HDL Cholesterol (mg/dl)	−4.14 (−2.99, −5.28)	<0.0001	−5.97 (−4.35, −7.59)	<0.0001
Cholesterol HDL Ratio	0.28 (0.38, 0.17)	<0.0001	0.43 (0.57, 0.3)	<0.0001
eGFR (mL/min/1.73m2)	−5.03 (−3.5, −6.55)	<0.0001	−4.27 (−2.56, −5.97)	0.0001
Creatinine (mg/dL)	0.04 (0.05, 0.03)	<0.0001	0.03 (0.05, 0.02)	<0.0001
Glucose ln(mg/dl)	0.01 (0.03, 0)	0.01	0.04 (0.05, 0.02)	0.0002
Insulin ln(mU/ml)	0.11 (0.15, 0.07)	<0.0001	0.16 (0.22, 0.1)	<0.0001
Adiponectin ln(mg/ml)	−0.09 (−0.05, −0.12)	0.0007	−0.15 (−0.1, −0.2)	<0.0001
Leptin ln(pg/ml)	0.61 (0.86, 0.36)	0.0003	0.42 (0.57, 0.27)	<0.0001
Percent Body Fat (%)	2.01 (2.83, 1.19)	0.0003	2.1 (2.91, 1.3)	<0.0001
Body Mass Index (kg/m2)	1.23 (1.5, 0.95)	<0.0001	2.27 (2.77, 1.76)	<0.0001
Whole Body Fat Mass ln(g)	0.16 (0.23, 0.1)	<0.0001	0.14 (0.18, 0.09)	<0.0001
Whole Body Lean Mass ln(g)	0.02 (0.04, 0.01)	0.0008	0.04 (0.06, 0.02)	<0.0001
Hemoglobin (g/dL)	0.19 (0.27, 0.11)	0.0002	0.22 (0.31, 0.12)	<0.0001
C Reactive Protein ln(mg/L)	0.2 (0.31, 0.1)	0.0002	0.28 (0.38, 0.18)	<0.0001
Hematocrit (%)	0.49 (0.71, 0.26)	<0.0001	0.65 (0.92, 0.38)	0.0003
ALT (U/L)	1.28 (1.98, 0.57)	0.0004	1.95 (2.68, 1.22)	<0.0001
Red Blood Cell Count (mill/mcl)	0.06 (0.08, 0.03)	<0.0001	0.08 (0.12, 0.05)	<0.0001
White Blood Cell Count (thous/mcl)	0.1 (0.22, −0.02)	0.09	0.27 (0.39, 0.15)	<0.0001
DBP (mmHg)	1.72 (2.52, 0.92)	<0.0001	0.67 (1.54, −0.21)	0.13
SBP (mmHg)	2.03 (3.12, 0.94)	0.0003	0.86 (2.42, −0.7)	0.28