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. 2009 Dec 1;4(12):e8107. doi: 10.1371/journal.pone.0008107

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Buscarlet et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Schematic representation of the Gro/TLE1 domain structure characterized by glutamine-rich (Q), glycine/proline-rich (GP), protein kinase CK2/cell cycle-dependent kinase 2/nuclear localization sequence (CcN), serine/proline-rich (SP), and WD40 repeat (WD) domains. (B) Sequence comparison of the N-terminal portion of the SP domain of human, mouse, zebrafish, and Xenopus Gro/TLE1, as well as Drosophila Gro. The location of Ser-286, Ser-289, and Ser-298 within the SP domain of Gro/TLE1 is indicated (top), as is the location of Ser-285, Ser-287, and Ser-298 of Drosophila Gro (bottom). Identical and conserved residues are highlighted in black or grey, respectively. (C) Tandem mass spectrum of the indicated phosphopetide from human Gro/TLE1; a sufficient number of Y_n ions (C-terminus-derived fragment ions) were detected to assign the phosphorylation site to Ser-286.