Figure 4. Schematic representation of putative S. mansoni TNF signal transduction pathway.

Orange elements were in silico identified in S. mansoni, blue elements were not found. Symbol (→) indicates covalent modification : protein phosphorylation; (}) indicates non-covalent interaction : association : protein/protein. Relations: (+), stimulatory; (−), inhibitory; (0), neutral; (?), undefined. Adapted from ref. [45]. Inside the nucleus (rectangles) we have highlighted two examples of messages whose transcriptions are described in humans to be mediated by c-Jun.