Table 3. Summary of Clinical Data from Published Case Reports of HBV Reverse Seroconversion^a.

				Pre-treatment						Post-treatment
Authors	Age	Sex	Diagnosis	HBsAg	anti HBs	anti HBc	HBV DNA	Intervention	Time to Reactivation	HBsAg	anti HBs	anti HBc	HBV DNA	Outcome
Wands et al.52	21	M	AML	Neg	Pos	Not done	Not done	Cytotoxic chemo	2 mos	Pos	Neg	Not done	Not done	Serologic resolution
Chen et al.55	35	F	SAA	Neg	Pos	Pos	Not done	Bone Marrow Transp	12 mos	Pos	Neg	Pos	Not done	Active/N.S.b
Lok35	N.S.	M	NHL	Neg	Pos	Pos	Negative	Cytotoxic chemoc	N/A	Pos	Neg	N.S.b	Detected	Carrier state
Dhedin et al.56	38	M	CML	Neg	Pos	Not done	Not done	Bone Marrow Transp	12 mos	Pos	Neg	pos	Detected	Serologic resolution
Dhedin et al.56	44	M	AML	Neg	Pos	Pos	Not done	Bone Marrow Transp	10 mos	Pos	Neg	pos	Detected	Hepatitis/N.S. b
Dhedin et al.56	44	M	SAA	Neg	Pos	Pos	Not done	Bone Marrow Transp	6 mos	Pos	Neg	pos	Detected	Serologic resolution
Dhedin et al.56	46	M	ALL	Neg	Pos	Pos	Not done	Bone Marrow Transp	18 mos	Pos	Neg	pos	Detected	Serologic resolution
Goyama60	59	M	Acute Leukemia	Neg	Pos	Pos	Not done	Bone Marrow Transp	6 mos	Pos	Neg	Neg	Detected	Serologic resolution
Goyama60	52	M	CML	Neg	Pos	Pos	Negative	Bone Marrow Transp	11 mos	Pos	Neg	Pos	Detected	Serologic resolution
Knoll et al.59	41	M	ALL	Neg	Pos	Pos	Detected	Bone Marrow Transp	14 mos	Pos	Neg	pos	Detected	Serologic resolution
Knoll et al.59	55	M	CML	Neg	Pos	Pos	Not done	Bone Marrow Transp	22 mos	Pos	Neg	pos	Detected	Carrier state
Knoll et al.59	51	M	CML	Neg	Pos	Not done	Detected	Bone Marrow Transp	12 mos	Pos	Neg	Not done	Detected	Carrier state
Iannitto et al.61	60	F	CLL	Neg	Pos	Pos	Detected	Alemtuzumab	4 weeks	Pos	Neg	Pos	Detected	Serologic resolution
Berger et al.62	75	M	PCKD	Neg	Pos	Pos	Negative	Renal transplant	5 yrs	Pos	Neg	Pos	Detected	N.S. b
Kempinska63	47	M	AML	Neg	Pos	Pos	Not done	Bone Marrow Transp	17 months	Pos	Neg	Pos	Detected	Chronic hepatitis
Gwak et al.37	66	F	Rheum Arthritis	Neg	Pos	Not done	Negative	Methotrexate	7 yrs	Pos	Neg	Neg	Detected	Fulminant liver failure, death
Awerkiew et al.64	36	M	NHL	Neg	Pos	Neg	Not done	Cytotoxic Chemo	5 yrs	Pos	Pos	Neg	Detected	Death
Giudice et al.65	13	M	AML	Neg	Pos	Pos	Detected	Bone Marrow Transp	6 mos	Pos	Neg	Neg	Detected	Chronic hepatitis
Oshima et al.66	42	F	ALL	Neg	Pos	Pos	Not done	Bone Marrow Transp	23 mos	Pos	Neg	Pos	Detected	Serologic resolution

^aPublished case series not included because they do not present individual-level clinical data⁵⁷: Seth et al.,⁵⁷ Onozawa et al.,⁵⁸ Uhm et al.⁵⁴

^bN.S., not specified

^cReverse seroconversion occurred prior to chemotherapy

CML, chronic myelogenous leukemia; SAA, severe aplastic anemia; AML, acute myelogenous leukemia; ALL, acute lymphoblastic leukemia; NHL, non-Hodgkins lymphoma; PCKD, polycystic kidney disease