Table 1. MMP and TIMP expression during endochondral ossificationa.
| Cell type | MMP or TIMP expressed | Refs |
|---|---|---|
| Proliferating chondrocytes | MMP10 (Stromelysin 2) | [19,20,40,41] |
| TIMP1-4 | ||
| Hypertrophic chondrocytes | MMP10 (Stromelysin 2) | [19,20,24,25,40,41] |
| MMP13 (Collagenase 3) | ||
| TIMP1-4 | ||
| Osteoclasts and resorptive cells | MMP10 (Stromelysin 2) | [7,11,19,31,32] |
| MMP9 (Gelatinase B) | ||
| MMP14 (MT1-MMP) | ||
| Osteoblasts and bone-lining cells | MMP3 (Stromelysin 1) | [19,25–27] |
| MMP13 (Collagenase 3) | ||
| Osteocytes | MMP3 (Stromelysin 1) | [19] |
| Endothelial cells | MMP10 (Stromelysin 2) | [7,19] |
| MMP9 (Gelatinase B) | ||
| Monocytes | MMP10 (Stromelysin 2) | [7,21,31,32] |
| MMP9 (Gelatinase B) |
a
Abbreviations: MMP, matrix metalloproteases; MT1-MMP, membrane-type 1 MMP; TIMP, tissue inhibitor of matrix metalloproteases.