. Author manuscript; available in PMC: 2010 May 14.

Published in final edited form as: J Med Chem. 2009 May 14;52(9):2733–2746. doi: 10.1021/jm801314f

Table 5. Distances between C_γ atoms (in Å) of selected residues for the analogues studied by NMR and the sst₁/sst₄- pharmacophores.

	F⁷ - X⁸	F⁷ - IAmp⁹	F⁷ - F¹¹	X⁸ - IAmp⁹	X⁸ - F¹¹	IAmp⁹-F¹¹
Sst₁ pharmacophore	6.0-7.5	9.0-11.0	6.0-7.5	7.0-8.0	9.5-12.0	8.0-10.0
Sst₄ pharmacophore	-	-	-	4.5-6.5	5.5-9.5	4.5-6.5
16	5.9-7.0	9.4-9.8	5.1-6.8	5.3-6.7	8.2-8.8	8.0-8.6
23	5.9-7.8	7.3-10.6	6.6-11.0	6.9-8.1	9.6-11.2	5.8-6.6
27	5.2-6.8	8.5-10.0	6.4-7.7	4.5-7.1	9.0-9.8	6.4-8.3

X refers to either DTrp or DAgl(NMe, 2naphthoyl) residues.

Table 5. Distances between Cγ atoms (in Å) of selected residues for the analogues studied by NMR and the sst1/sst4- pharmacophores.