Fig. 1. Regulation of histone acetylation and methylation at gene promoters in the NAc by chronic cocaine.
A. Venn diagrams of genes that show altered levels of H3 or H4 acetylation and H3 methylation (dimethyl-K9/K27) binding 24 hrs after chronic (7 days) cocaine administration. B. Patterns of cocaine-induced changes in H3 and H4 acetylation and H3 methylation at 6 representative gene promoters previously implicated in cocaine action.