Figure 7.

Schematic model illustrating how Jun proteins regulate the TIMP-3, TACE, and TNFα pathway: Jun proteins transcriptionally activate TIMP-3 expression, which is responsible for TACE inhibition. The absence of JunB and c-Jun leads to an increase in TACE activity, followed by increased levels of sTNFα, which signals through TNFR1, inducing more TNFα RNA and TNFα-dependent cytokines. This cascade causes skin inflammation leading to a psoriasis-like disease in adult mice and to skin inflammation and cachexia with perinatal death in newborns.