Table 3.
EC50 values for RAL, MK-2048 and EVG for subtype B and C viruses cultured in cord blood mononuclear cells.
| Subtype B | EC50 Values (μM) | ||
|---|---|---|---|
| Viruses | RAL (μM) | MK-2048 (μM) | EVG (μM) |
| 5326 | 0.0243 ± 0.0025 | 0.0072 ± 0.0021 | NDa |
| 5331 | 0.0056 ± 0.0022 | 0.0010 ± 0.0002 | 0.0001 ± 0.00007 |
| BK 132 | 0.0301 ± 0.0054 | 0.0148 ± 0.0032 | NDa |
| pNL4-3 | 0.0082 ± 0.0013 | 0.0027 ± 0.0009 | 0.0009 ± 0.0003 |
| IIIb | 0.0012 ± 0.0005 | 0.0003 ± 0.0001 | 0.0018 ± 0.0006 |
| Subtype C | EC50 Values (μM) | ||
| Viruses | RAL (μM) | MK-2048 (μM) | EVG (μM) |
| Mole 03 | 0.0046 ± 0.0002 | 0.0011 ± 0.0001 | NDa |
| 96USNG31 | 0.0087 ± 0.0007 | 0.0015 ± 0.0001 | 0.0008 ± 0.0006 |
| 4742 | 0.0206 ± 0.0090 | 0.0033 ± 0.0020 | 0.0022 ± 0.0002 |
| BG-05 | 0.0067 ± 0.0009 | 0.0022 ± 0.0007 | 0.0008 ± 0.00004 |
| HB-1 | 0.0015 ± 0.0004 | 0.0007 ± 0.0005 | 0.0001 ± 0.00001 |
aND = not done