Table 3.
RR of the HLA-A alleles (>0.01 frequency) without and with conditioning on HLA-DRB1, HLA-DQB1 and HLA-B
| HLA-A allele | Frequency in affected offspring, N (%) |
Frequency in parents*, N (%) |
Unconditional RR (95% CI) |
RR (95% CI) conditional on HLA-DRB1/ HLA-DQB1 (BIC) |
RR (95% CI) conditional on HLA-DRB1/ HLA-DQB1 (AIC) |
OR (95% CI) conditional on HLA-DRB1/ HLA-DQB1 from [1] |
|---|---|---|---|---|---|---|
| HLA-A*24 | 977 (10.84) | 705 (9.72) | 1.32 (1.13–1.54) | 1.34 (1.13–1.59) | 1.22 (1.02–1.46) | 1.54 (1.11–2.11) |
| HLA-A*33 | 87 (0.97) | 81 (1.12) | 0.83 (0.57–1.19) | 0.90 (0.62–1.30) | 1.02 (0.67–1.55) | 0.63 (0.25–1.60) |
| HLA-A*02 | 3097 (34.36) | 2324 (32.03) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
| HLA-A*29 | 258 (2.86) | 231 (3.18) | 0.73 (0.58–0.91) | 0.84 (0.65–1.10) | 0.96 (0.73–1.26) | 0.85 (0.53–1.35) |
| HLA-A*03 | 1130 (12.54) | 955 (13.16) | 0.86 (0.75–0.99) | 0.90 (0.76–1.06) | 0.91 (0.76–1.09) | 1.17 (0.87–1.58) |
| HLA-A*23 | 102 (1.13) | 116 (1.60) | 0.55 (0.39–0.77) | 0.80 (0.56–1.12) | 0.81 (0.56–1.18) | 0.51 (0.22–1.17) |
| HLA-A*26 | 181 (2.01) | 171 (2.36) | 0.70 (0.54–0.91) | 0.67 (0.50–0.91) | 0.79 (0.57–1.08) | 0.63 (0.34–1.16) |
| HLA-A*31 | 192 (2.13) | 165 (2.27) | 0.94 (0.72–1.23) | 0.72 (0.53–0.96) | 0.78 (0.57–1.05) | 0.41 (0.24–0.69) |
| HLA-A*68 | 249 (2.76) | 228 (3.14) | 0.73 (0.57–0.94) | 0.76 (0.57–1.01) | 0.74 (0.55–1.01) | 0.84 (0.52–1.36) |
| HLA-A*30 | 352 (3.91) | 239 (3.29) | 1.33 (1.05–1.70) | 0.99 (0.76–1.30) | 0.73 (0.54–0.99) | 0.89 (0.50–1.57) |
| HLA-A*01 | 1682 (18.66) | 1292 (17.81) | 1.09 (0.97–1.23) | 0.73 (0.63–0.84) | 0.73 (0.60–0.88) | 0.58 (0.43–0.79) |
| HLA-A*11 | 312 (3.46) | 352 (4.85) | 0.54 (0.44–0.66) | 0.67 (0.52–0.85) | 0.71 (0.55–0.91) | 0.47 (0.30–0.73) |
| HLA-A*25 | 202 (2.24) | 162 (2.27) | 1.01 (0.76–1.35) | 0.82 (0.61–1.10) | 0.66 (0.48–0.91) | 0.62 (0.31–1.23) |
| HLA-A*32 | 173 (1.92) | 209 (2.88) | 0.52 (0.40–0.68) | 0.55 (0.41–0.74) | 0.59 (0.43–0.82) | 0.64 (0.39–1.04) |
AIC, Akaike information criteria; BIC, Bayesian information criteria; CI, confidence interval; HLA, human leucocyte antigen; OR, odds ratio; RR, relative risks.
HLA-A*02 is used as reference. Conditioned RR with corresponding 95% CI are presented using the BIC tree, which give results consistent with the Nejentsev et al. in [1]. Alleles that are significantly protective or susceptible in both studies are highlighted in bold.
*
Parents who were known to have type 1 diabetes were removed from the frequency calculations.