Figure 2. MsDps2 forms protein-DNA nucleoid-like structures under transmission electron microscope. A (1–3) MsDps2 forms ring-like structures and arrays.

Purified MsDps2 protein shows ring-like doughnut-shaped dodecamers under the transmission electron microscope. A single particle is shown with the thin arrow. The protein was also seen to form arrays as shown in the region covered with the solid arrow. B (1–2) MsDps2 protein forms nucleoid-like structures in vitro . Transmission electron microscopic analysis of the MsDps2 protein bound to DNA showed nucleoid-like structures similar to those observed for the E.coli suggesting a role in the condensation and organization of the mycobacterial nucleoid for the MsDps2 protein. C) MsDps2 protein shows tightly compacted stationary phase nucleoid-like structure.