Table 3. Effect of DNA repair and replication mutations on B. burgdorferi infection in SCID C3H/HeN mice.
| B. burgdorferi genotype | Strain (GCB) | Total micea | Day 7 Bloodb | Day 7 Infection | Day 21 Ear | Day 21 Infection | Day 35 | Persistence at day 35 | ||||
| Heart | Bladder | Joint | Ear | Total sitesc | ||||||||
| 5A4 wt | 933 | 6 | 6/6 | 100.0% | 6/6 | 100.0% | 6/6 | 6/6 | 6/6 | 6/6 | 24/24 | 100.0% |
| recJ1 (BB0254)recJ5 | 11531154 | 4 | 2/22/2 | 100.0% | 2/22/2 | 100.0% | 2/22/2 | 2/22/2 | 2/22/2 | 2/22/2 | 8/88/8 | 100.0% |
| ruvB4 (BB0022)ruvB5 | 513514 | 4 | 2/22/2 | 100.0% | 2/22/2 | 100.0% | 2/22/2 | 2/22/2 | 2/22/2 | 2/22/2 | 8/88/8 | 100.0% |
| ruvA1 (BB0023)ruvA2 | 11741175 | 4 | 2/22/2 | 100.0% | 2/22/2 | 100.0% | 2/22/2 | 2/22/2 | 2/22/2 | 2/22/2 | 8/88/8 | 100.0% |
| mutL1 (BB0211)mutL2 | 11781179 | 4 | 1/21/2 | 50.0% | 2/22/2 | 100.0% | 2/22/2 | 2/22/2 | 2/22/2 | 2/22/2 | 8/88/8 | 100.0% |
| sbcD1 (BB0829)sbcD2 | 12511252 | 4 | 2/22/2 | 100.0% | 2/22/2 | 100.0% | 2/22/2 | 2/22/2 | 2/22/2 | 2/22/2 | 8/88/8 | 100.0% |
| sbcC2 (BB0830)sbcC3 | 12481249 | 4 | 2/22/2 | 100.0% | 2/22/2 | 100.0% | 2/22/2 | 2/22/2 | 2/22/2 | 2/22/2 | 8/88/8 | 100.0% |
| BBG32/6BBG32/7 | 12331234 | 4 | 2/22/2 | 100.0% | 2/22/2 | 100.0% | 2/22/2 | 2/22/2 | 2/22/2 | 2/22/2 | 8/88/8 | 100.0% |
a
Total number of mice examined for genotype.
b
Values listed correspond to number of cultures positive/number of sites tested.
c
Number of positive tissue sites/number of sites tested.