Fig. 2.

Effect of Haloperidol and Sulpiride on Plateau Potentials Exhibited by Nigral Dopamine-Containing Neurons In Vitro. (A) Intracellular recording obtained from a spontaneously active dopamine neuron in vitro in the presence of the negative SK channel modulator, NS8593.⁶⁴ Note the “burst” of spikes on the rising phase of a depolarizing plateau potential. Addition of TTX blocks spiking but has no effect on the underlying plateau potential (B and C, black traces). Bath application of haloperidol (C, gray trace) but not sulpiride (B, gray trace) prolongs the duration of plateau potentials recorded in the presence of the SK channel pore blocker, apamin. Modified from Canavier et al.⁸