Table 7.
Candidate genes for non-OMIM PARK loci
| GenBank ID | Human ID | Symbol | Human location | In kbb | Gene name | |
|---|---|---|---|---|---|---|
| Scott (01) D3S246026 | ||||||
| 5 | NM_008083 | NM_002045 | GAP43 | 3q13.1–13.2 | 116700 | Growth-associated protein 43 |
| 3 | BB626331 | EST | Lsamp | 3q13.2–q21 | 117200 | Limbic system-associated membrane protein |
| 2 | NM_177093 | XM_057296 | LRRC58 | 3q13.33 | 121300 | Leucine-rich repeat containing 58 |
| 2 | NM_008047 | NM_007085 | FSTl | 3q13.32–q13.3 | 121460 | follistatin-like 1 |
| Martinez (04) D5S47129 | ||||||
| 1 | XM_283496 | NM_005509 | DMXL1 | 5q22 | 118600 | Dmx-like 1 |
| 1 | Genomic | Estimated | FEM1C | 5q22 | 114939 | fem-1 homolog c |
| 3 | NM_152809 | NM_004384 | CSNK1G3 | 5q23 | 123000 | Casein kinase 1, gamma 3 |
| Li (02) D5S1462 D5S145321 | ||||||
| 1 | NM_172827 | EST | LNPEP | 5q15 | 96440 | Leucyl/cystinyl aminopeptidase |
| Hicks (02). Scott (01) D5S666. D5S81626,55 | ||||||
| 1 | NM_173753 | NM_001008738 | FNIP1 | 5q31.1 | 131060 | Folliculin interacting protein 1 |
| 1 | NM_144823 | NM_015256 | ACSL6 | 5q31 | 131400 | Acyl-CoA synthetase long-chain family member |
| 1 | NM_033144 | XM_034872 | SEPT8 | 5q31 | 132180 | Septin 8 |
| 1 | AK011363 | NM_003337 | UBE2B | 5q23–q31 | 133800 | Ubiquitin-conjugating enzyme E2B, RAD6 homology |
| Scott (01) D5S81626 | ||||||
| 1 | NM_029518 | NM_016604 | JMJD1B | 5q31 | 137810 | Jumonji domain containing 1B |
| 3 | NM_010771 | NM_018834 | MATR3 | 5q31.3 | 138730 | Matrin 3 |
| Li (02) D6S101721 | ||||||
| 1 | NM_025365 | NM_013397 | C6ORF49 | 6p21.31 | 41800 | Chromosome 6 open reading frame 49 |
| 1 | NM_020493 | NM_003131 | SRF | 6p21.1 | 43200 | Serum response factor (c-fos serum response element-binding transcription factor) |
| 5 | NM_008302 | NM_007355 | HSP90AB1 | 6p12 | 44300 | Heat shock protein 90 kDa alpha (cytosolic), class B member 1 |
| Martinez (04) D6S257 D6S46029 | ||||||
| 1 | Genomic | Estimated | 6q12–q13 | 72500 | ||
| 8 | NM_010106 | NM_001402 | EEF1A1 | 6q14.1 | 74224 | Eukaryotic translation elongation factor 1 alpha 1 |
| Martinez (04) D7S53129 | ||||||
| 1 | NM_028469 | NM_032350 | MGC11257 | 7p22.3 | 850 | Hypothetical protein MGC11257 |
| 1 | NM_010302 | NM_007353 | GNA12 | 7p22–p21 | 2510 | Guanine nucleotide binding protein (G protein) alpha 12 |
| 6 | NM_007393 | NM_001101 | ACTB | 7p15–p12 | 5300 | Actin beta |
| 1 | NM_026050 | NM_032706 | MGC12966 | 7p22.2 | 6110 | Hypothetical protein MGC12966 |
| 1 | NM_009007 | NM_006908 | RAC1 | 7p22 | 6170 | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac) |
| DeStefano (01) D9S1825,56 Scott (01) D9S30126 | ||||||
| 7 | NM_026434 | NM_033117 | RBM18 | 9q34.11 | 120400 | RNA binding motif protein 18 |
| 2 | NM_022310 | NM_005347 | HSPA5 | 9q33–q34.1 | 123370 | Heat shock 70 kD protein 5 |
| 1 | NM_025709 | NM_015635 | GAPVD1 | 9q34.11 | 123450 | GTPase-activating protein and VPS9 domains 1 |
| 1 | NM_172661 | XM_497080 | KIAA0515 | 9q34.1 | 129650 | KIAA0515 gene |
| DeStefano (01) GATA121A0856 | ||||||
| 1 | NM_183295 | NM_015634 | KIAA1279 | 10q22.1 | 70100 | KIAA1279 gene |
| Martinez (04) D11S417529 | ||||||
| 1 | NM_025844 | NM_012124 | CHORDC1 | 11q14.3 | 89650 | Cysteine and histidine-rich domain (CHORD)-containing. zinc-binding protein 1 |
| Li (02) D10S123921 | ||||||
| 1 | NM_172523 | NM_003054 | VMAT2 | 10q25 | 118680 | Solute carrier family 18 |
| Li (02) D17S130321 | ||||||
| 1 | NM_018768 | NM_004853 | STX8 | 17p12 | 9350 | Syntaxin 8 |
| Scott (01) D17S921, D17S129326 | ||||||
| 1 | NM_011664 | NM_018955 | UBB | 17p12–p11.2 | 16470 | Ubiquitin B |
| 1 | NM_011480 | NM_004176 | SREBF1 | 17p11.2 | 17950 | Sterol regulatory element binding factor 1 |
| 1 | XM_110937 | NM_145809 | USP32 | 17p11.2 | 18621 | Ubiquitin-specific protease 32 |
| 1 | NM_026389 | NM_015584 | POLDIP2 | 17q11.2 | 26800 | Polymerase delta interacting protein 2 |
| 1 | NM_174852 | NM_020889 | PHF12 | 17q11.1 | 27400 | PHD finger protein 12 |
| 1 | NM_010897 | NM_000267 | NF1 | 17q11.2 | 29700 | Neurofibromatosis 1 |
| 1 | NM_010161 | NM_014210 | EVI2A | 17q11.2 | 29800 | Ecotropic viral integration site 2A |
| 1 | NM_010716 | NM_002311 | LIG3 | 17q11.2–q12 | 33450 | Ligase III, DNA, ATP-dependent |
| Bertoli-Avella (03) D19S22127 | ||||||
| 2 | NM_008319 | NM_003259 | ICAM5 | 19p13.2 | 10260 | Intercellular adhesion molecule 5, telencephalin |
| 16 | NM_016742 | NM_007065 | CDC37 | 19p13.2 | 10370 | Cell division cycle 37 homolog (S. cerevisiae)-like |
| 1 | NM_145624 | NM_016264 | ZNF44 | 19p13.2 | 12200 | Zinc finger protein 44 |
| 1 | NM_010906 | NM_002501 | NFIX | 19p13.3 | 13030 | Nuclear factor I/X |
| 1 | NM_183097 | Estimated | 19p13.13 | 14060 | Progestin and adipoQ receptor family member | |
| DeStefano (02) D20S47856 | ||||||
| 1 | BQ927659 | Estimated | 20q11.2–q12 | 35330 | ||
| 1 | NM_013865 | NM_022477 | NDRG3 | 20q11.21–q11.23 | 36000 | n-myc downstream regulated 3 |
| 1 | NM_010658 | NM_005461 | MAFB | 20q11.2–q13.1 | 40000 | v-maf musculoaponeurotic fibrosarcoma oncogene family. protein B |
| 2 | NM_021464 | NM_007050 | PTPRT | 20q12–q13 | 40500 | Protein tyrosine phosphatase. receptor type T |
| DeStefano (02) D21S205256 | ||||||
| 2 | NM_11782 | Estimated | ADAMTS5 | 21q21.2 | 27170 | A disintegrin-like and metalloprotease (reprolysin-type) with thrombospondin type 1 motif 5 (aggrecanase-2′) 3′ |
| Pankratz (03) DXS805524 | ||||||
| 1 | NM_016783 | NM_006667 | PGRMC1 | Xq24 | 116713 | Progesterone receptor membrane component 1 |
Listed genes are situated ± 3 Mb to peak with the highest LOD score, except for D10S196 where we used ± 8Mb.
aNumber of cDNA fragments aligning with the gene.
bkb from the top of the short arm of the chromosome.
cHuman chromosome location was estimated by comparing the flanking regions of mouse and man.