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. Author manuscript; available in PMC: 2010 Oct 20.
Published in final edited form as: Biochemistry. 2009 Oct 20;48(41):9801–9809. doi: 10.1021/bi901024m

Table 2.

Binding of OA to Oxidized Mutant DHODs, pH 8.5, 25 °C

Enzyme Kd (µM)
Wild-Typea 3.4 ± 0.8
Ser175Ala 9.9 ± 0.9
Thr178Ser 1.1 ± 0.4
Thr178Ala 6.1 ± 0.8
Thr178Val 0.56 ± 0.04
Phe115Ala 3.8 ± 0.5
Phe115Leu 3.7 ± 0.3
Phe115Trp 8.1 ± 0.4
Phe115Leu/Thr178Val 4.6 ± 0.3
a

Data taken from (18).