Table 3. Quantitation of Elastase-digested fibrin degradation products in plasma samples.
TGN was induced in WT or Mac-1-/- mice and plasma from mice at the indicated times following TGN were examined for NE activity by examining fibrin degradation products reported to be specifically generated by granulocyte-elastase (e-XDP).
| Day | 0 | 1 | 2 | 4 |
|---|---|---|---|---|
|
Wild-type (μg/ml) |
0.06 ± 0.06 (n=4) |
2.26 ± 0.17 (n=12) |
1.69 ± 0.19 (n=5) |
1.97 ± 0.28 (n=4) |
|
Mac-1-/- (μg/ml) |
0.01 ± 0.01 (n=4) |
1.68 ± 0.16 (n=12) |
1.04 ± 0.29 (n=4) |
2.30 ± 0.67 (n=4) |
| p value | 0.40 | 0.02 | 0.09 | 0.66 |