Table 4. Side effects of IGF-1 therapy as reported in different studies^*1.

Study	Ranke et al. (16)	Guevara et al. (15)		Chernausek et al. (20)
Event		Placebo	IGF-I
	N = 33	N = 9	N = 7	N = 76
Hypoglycemia	13 (39%)	6 (67%)	6 (87%)	37 (49%)
Tonsillar/adenoidal				17 (22%)
hypertrophy
Tonsillectomy/	2 (9%9			17 (22%)
adenotomy
Hypertrophy				8 (35%)
of the thymus
Sleep apnea				3 (4%)
Lipohypertrophy	7 (21%)			24 (32%)
at injection site
Headache	21 (64%)	2 (22%)	2 (29%)
Pain at injection site	16 (48%)	3 (33%)	3 (43%)

^*1 Side effects are documented systematically in these studies