. Author manuscript; available in PMC: 2010 Jun 25.

Published in final edited form as: J Med Chem. 2009 Jun 25;52(12):3742–3752. doi: 10.1021/jm9001296

Table 2.

K_i values for the inhibition of hiCE-mediated hydrolysis of 1 by selected benzene sulfonamides. Inhibition constants using 3 are included for comparison.

ID	K_i 1 (nM)	K_i 3 (nM)
4	>100,000^a	218 ± 45^a
5	3,220 ± 950^a	1,310 ± 176^a
6	>100,000^a	165 ± 33^a
7	>100,000^a	767 ± 285^a
8	892 ± 67^a	1,060 ± 133^a
9	238 ± 29^a	365 ± 87^a
10	>100,000	194 ± 23^a
11	141 ± 64^a	53.2 ± 5.5^a
12	>100,000	451 ± 39^a
13	110 ± 23^a	41.5 ± 6.5^a
15	152 ± 29	248 ± 26
16	79 ± 15	355 ± 70
17	62 ± 15	74.0 ± 5.5
18	121 ± 15^b	67.0 ± 9.6^b
19	44 ± 10	85.2 ± 10.1
20	>100,000	5,260 ± 620
23	192 ± 44	210 ± 33
46	>100,000	>100,000
50	>100,000	3,240 ± 1,780
52	>100,000	2,600 ± 1,010
54	28 ± 4^b	23.4 ± 2.7^b

Data taken from Wadkins et al.²¹

Data taken from Hatfield et al (manuscript in preparation).