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. Author manuscript; available in PMC: 2009 Nov 20.
Published in final edited form as: Protein Expr Purif. 2007 Apr 3;54(2):275–282. doi: 10.1016/j.pep.2007.03.017

Figure 1. The structures of LOC387715 and its predicted mRNA and 2 cDNA clones.

Figure 1

A. Hypothetical LOC387715. It contains one intron and 2 exons (nt1-362, and nt2245–2690) at both ends. B. The predicted mRNA of LOC387715 (XM_373477). C. The NIH MGC cDNA clone BC066349 of LOC387715. D. The NIH MGC cDNA clone BC090924 of LOC387715. The major difference between XM_373477 and BC066349 is that the later had a deletion of 2 adjacent nucleotides (ac) at nt469–470. The major difference between XM_373477 and BC090924 is that the later at nt71 and nt760 has different nucleotides (a rather than g for nt71 - which causes the 3rd aa of the predicted protein to be His rather than Arg, and g rather than t for nt760). ORF – open reading frame, nt – nucleotides, and rs10490924 – the coding polymorphism that is associated with the risk of AMD.