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Inhibition of survivin by SN-38 is associated with increased p38 MAPK phosphorylation. MCF-7 cells were treated with SN-38 for 2 hrs and then without drug over the time indicated. Cells were then lysed and analyzed for the phosphorylation of p38 and ErbB2 by western blots using phospho-p38-specific or phospho-ErbB2-specific antibodies. Total p38 protein was monitored as an internal control.
