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Inhibition of SN38-induced activation of p38 MAPK alleviates SN38-mediated inhibition of survivin expression. MCF-7 breast cancer cells were treated with SN-38 in the presence and absence of p38 kinase inhibitors as shown. Cells were lysed 24 hours after treatment and analyzed for survivin expression by western blots as shown. β-Action was used as an internal control for equal protein loading.
